RIP Raptiva?

Arie Rip

Rip Currents

Scientific T To examine the spatial and temporal variability of rip currents using remote video imaging techniques. T To quantify changes in nearshore circulation and topography in response to varying incident wave conditions at different time scales including; P wave groupiness (time scales of 1-10 minutes), P tidal modulation (time scales of 12h and 24 h) and P wave height fluctuations associ...

Assessing long-term drug safety: lessons (re) learned from raptiva.

Efalizumab was approved for moderate to severe psoriasis in 2003 based on studies in approximately 2700 patients, of whom only 218 were exposed to the drug for more than 1 year. In 2009, after more than 46,000 patients were exposed to efalizumab, the drug was withdrawn from the market after 3 confirmed and 1 suspected case of progressive multifocal leukoencephalopathy (PML) were spontaneously r...

RCEX: Rip Current Experiment

The long-term goals are to understand surf zone processes related to rip current systems through field observations. Rip currents occur commonly on most beaches and dominate many. It is recognized that beaches with straight and parallel contours are not a stable morphologic configuration whereas more complex beaches, which support the existence of rip current morphology, are stable and more com...

RIP-chip enrichment analysis

MOTIVATION RIP-chip is a high-throughput method to identify mRNAs that are targeted by RNA-binding proteins. The protein of interest is immunoprecipitated, and the identity and relative amount of mRNA associated with it is measured on microarrays. Even if a variety of methods is available to analyse microarray data, e.g. to detect differentially regulated genes, the additional experimental step...